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Organic Jujube 1kg – Sun-Dried, Raw-Food, Vegan & Untreated Red Date Berries

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Cancer: One group of researchers tested jujube’s effects on human cervical and breast cancer cells. Their results suggest jujube may hold promise in preventing or treating cancer. It’s important to note these studies were conducted in isolated cancer cells (think: Petri dishes, not people). The presence of bioactive compounds in jujube prevents your body from falling prey to free radical cell development, which cause symptoms associated with cancer. The antioxidant property of jujube makes it effective in combating cancer and other heart diseases. Experts say that you may also want to avoid eating jujube fruit if you take antidepressant drugs like venlafaxine. Jujube may interact with such drugs. When you get down to it, jujube may have some very positive health effects. But that doesn’t mean you need to load up on it right away. Jujube tree is important in Hinduism too as Vishnu is worshipped in a major temple, in Badrinath, from the Sanskrit compound Badarīnātha, consisting of the terms badarī ( jujube tree) and nātha (lord), an epithet of Vishnu. [38] It is also known as Badarikashrama.

When products like jujube are used for certain purposes over hundreds of years, there’s often good reason for it,” says registered dietitian Sarah Thomsen Ferreira, RD, LD. “Foods tend to gain a reputation for a reason, so their historical use can be informative. Research data on Jujube in human health, however, is limited.” Heme oxygenase-1 (HO-1) has a vital role in metabolizing heme to biliverdin, carbon monoxide and free iron. Biliverdin is immediately conversed to bilirubin, as catalyzed by biliverdin reductase containing two isozymes, i.e., biliverdin reductase A and B. Free iron is released to blood circulation by ferroportin and further carried to bone marrow ( Kovtunovych et al., 2010). Therefore, HO-1, biliverdin reductase and ferropotin are considered as the main target enzymes in determining the iron recycling in macrophages. Jujube extract at different concentration (0–3.0mg/ml) was applied onto cultured macrophages for 24h. The applied jujube extract stimulated the mRNA expressions of HO-1, biliverdin reductase A and B, and ferropotin in dose-dependent manners, giving the highest response by ∼2.0, 2.0, 3.0, and 4.0 folds, respectively ( Chen J. et al., 2016). In good agreement with this finding, Yang et al. (2016) reported that the intake of jujube extract showed an improvement in iron deficiency anemia rats. In parallel, the extract of jujube significantly increased serum iron, iron saturation, total iron binding capacity in anemia rats, indicating the supply of circulation iron for erythropoiesis. Nuclear factor (erythroid-derived 2)-like 2 (Nrf2), a transcription factor, was found to regulate HO-1 expression ( Motohashi and Yamamoto, 2004). Nrf2 directly binds to anti-oxidant response element (ARE) in the promoter region of HO-1 gene resulting in the transcription. In pARE-Luc-expressed cells treated with jujube water extract, the luciferase assay was activated in a dose-dependent manner ( Chen J. et al., 2016). The activation by two folds was confirmed under application of jujube extract at 3.0mg/ml ( Chen J. et al., 2016). This result suggests the involvement of Nrf2/HO-1 signaling in jujube-treated cells. In support of this notion, Almeer et al. (2018) revealed the effects of jujube extract on gene expressions of Nrf2 and HO-1 in colitis rats, as induced by treating intrarectally with acetic acid. Compared with model group, the pre-treatment with jujube extract at different doses (100, 200, and 400mg/kg/day) in colon of rats for 5days by oral gavage significantly induced mRNA expressions of Nrf2 and HO-1, giving the highest response by seven and two folds, respectively ( Almeer et al., 2018). These studies however need further confirmation as no observation has been found in a physiology model of iron recycling. For instance, a cellular model of erythrophagocytosis using artificially-aged RBCs and macrophages may be designed to investigate mRNA and protein expressions of target enzymes relating to iron recycling. Jujube on Immune Functions The original contributions presented in this study are included in the article/ Supplementary Material, further inquiries can be directed to the corresponding authors. Author Contributions Depending on the size of the fruit, eating one to three jujube fruits will meet the daily vitamin C recommendations of 90 milligrams for men and 75 milligrams for women. Are There Side Effects from Eating Jujube Fruit?The hydroalcoholic extract of jujube at 200–400mg/kg was applied onto acute and chronic rat models of inflammation. The study revealed that jujube extract markedly declined granuloma tissue formation, as compared with model rat. Serum nitrite/nitrate level was notably up regulated in inflammatory rat; while pre-treatment with jujube significantly reduced the increased level of nitrite/nitrate ( Goyal et al., 2011). These findings suggest the anti-inflammatory effects of jujube. In line with this, the applied jujube extract at 100–500μg/ml inhibited nitric oxide production and splenocyte proliferation on the inflammatory activated cells ( Yu et al., 2012). The excessive induction of pro-inflammatory cytokines, i.e., IL-1β and IL-6, also contributes to chronic inflammation. In the lipopolysaccharide (LPS)-induced macrophages, the pre-treatment with jujube water extract repressed the expressions of IL-1β and IL-6 ( Chen et al., 2014a). Besides, the triterpene acid fraction of jujube at a dose higher than 10μg/ml was able to inhibit the production TNF-α ( Yu et al., 2012). NF-κB is one of main transcription factors that has vital role in controlling pro-inflammatory cytokine production ( Du et al., 2013). The treatment with jujube extract slightly inhibited NF-κB activity. On the other hand, the pre-treatment with jujube water extract (0–3mg/ml) for 3h in cultured macrophages, before the addition of LPS at 1μg/ml for 24h, dose-dependently repressed the activation of NF-κB activity. The reduction at 60% was observed under the pre-treatment of extract at 3mg/ml ( Chen et al., 2014a). In parallel, the anti-inflammatory property of jujube was shown in colitis-associated colon cancer mice ( Periasamy et al., 2020). In this study, mice were injected with azoxymethane followed by three cycles of dextran sulfate sodium, as to induce colitis-associated colon, before the intake of jujube extract for 70days. The results showed that dietary jujube intake could attenuate inflammation in model mice. Moreover, the extract of jujube markedly inhibited the protein expressions of IL-6, NF-κB, JAK1, and STAT3 in colon tissues, as compared with model group. This result suggests that jujube can suppress the stimulation of NF-κB/IL-6/JAK1/STAT3 signaling ( Periasamy et al., 2020). Jujube in Blood Circulation The H 2O 2 content was carried out based on titanium sulfate colorimetric method, with slight modifications ( 38). First, 0.1 g of freeze-dried jujube powder was decolored using 2 ml pre-cooled acetone, accompanied by grinding for 1 min. The mixture (∼2 ml) was collected, the residual jujube powder in mortar was washed by another 3 ml acetone, and 5 ml of jujube-acetone mixture was obtained. After centrifugation at 5,600 × g for 15 min, 1 ml of supernatant was added to a 2-ml tube, and 100 μl of 5 % titanous sulfate regnant and 200 μl of ammonium hydroxide were successively added. After reaction for 5 min and centrifuged at 5,600 × g for 10 min, the precipitate was preserved and used for next procedure. Finally, the precipitate was washed by acetone for two times and 1.5 ml of 2 M vitriol solution was added. The absorbance value of 150 μl reaction solution was obtained at 415 nm. The standard curve was built using different concentrations of H 2O 2 solution by the same processing. The results were expressed as mmol kg –1 dry weight (mmol kg –1 DW). In Vietnam and Taiwan, fully mature, nearly ripe fruit is harvested and sold on the local markets and also exported to Southeast Asian countries. [21] The dried fruit is used in desserts in China and Vietnam, such as ching bo leung, a cold beverage that includes the dried jujube, longan, fresh seaweed, barley, and lotus seeds. [21] People who suffer from anxiety and long term stress are recommended to consume the fruit raw or in juice form. The fruit contains a good amount of anxiolytics, which help soothe the body and are known positively impact your hormonal levels, preventing the body from the effect of stress hormones such as cortisol. 4. Anti Cancer Effect

It comes down to the pros and the cons of nutritional benefits versus accessibility,” Thomsen Ferreira advises. “You can get a similar amount of vitamin C and potassium from other foods that are more readily available in certain areas than jujube.” With the passage of time your bones become weak and including jujube in your diet can help you to stay away from bone diseases such as osteoporosis. As it contains rich amounts of calcium, minerals, phosphorous and iron, eating the fruit daily can help steer your clear of a lot of bone related health complications. 3. Good for Eliminating Anxiety and StressAccordingly, the objective of this study was to apply CAP pretreatment to delay ripening and senescence of jujube. Finally, our work will provide a theoretical support for proposing CAP as an effective storage and preservation strategy for jujube fruit. Materials and Methods Jujube Processing Three ounces of jujube are estimated to have between 275 and 541 milligrams of phenols. The next best source is cherries, with about 114 milligrams per 3 ounces. Polysaccharides from plant have been demonstrated to possess various bio-activities, e.g., anti-oxidation, anti-complementary and immunological activities ( Li et al., 2003; Gao et al., 2007; Chen M. et al., 2016). Several polysaccharides have been isolated and purified from the jujube. The polysaccharides extracted from jujube usually consist of five monosaccharides, i.e., galactose, arabinose, rhamnose, glucose and xylose ( Zhao et al., 2008) ( Figures 3B). Fractions named as ZSP1, ZSP2, ZSP3 and ZSP4 with weight ratio of 29.3:17.6:37.2:15.9 have been purified from jujube ( Li et al., 2011). The fractions of ZSP3 and ZSP4 at various concentrations (30–200μg/ml) were applied onto peritoneal macrophages, and the cell proliferation was detected by MTT assay. These two fractions were found to dose-dependently induce proliferation of spleen lymphocyte, having the highest response under the treatment of jujube polysaccharide at 200μg/ml. This finding suggests the immunological activity of jujube polysaccharide. In line with this, Ju-B-2, a molecular weight of over 2,000kDa polysaccharide from jujube, was shown to have the immune activity. Application of Ju-B-2 at 10–100μg/ml onto cultured spleen cells for 3days induced cell proliferation. Furthermore, the authors proposed the structures of rhamnogalacturonan and its side chains of Ju-B-2 polysaccharide contributing to the immune response ( Zhao et al., 2006). Although several reports support the beneficial effects of jujube polysaccharides in preventing anemia, its detail action mechanisms are still rather limit. Hence, possible signaling pathways involved in jujube polysaccharide-treated in vitro or in vivo models are needed for further investigation. As seen in Figure 3, the result demonstrated that 5-, 10-, and 20-min CAP treatment all have no impacts on TAB count as compared to control. This may be due to 200 μl L –1 sodium hypochlorite displayed a brilliant disinfect effect on Jujube and then, the TAB count stood in a safe range ( 35). Our result was in good agreement with the finding of Won et al., who formulated that P. italicum were reduced by microwave-powered cold plasms from 96.6 to 85.0 and 16.0% with an independent input power manner ( 46). Furthermore, low/ice temperature environment is strictly unfavorable for bacteria growth and proliferation ( 47). On his visit to Medina, the 19th-century English explorer, Sir Richard Burton, observed that the local variety of jujube fruit was widely eaten. He describes its taste as like "a bad plum, an unripe cherry, and an insipid apple". He gives the local names for three varieties as "Hindi (Indian), Baladi (native), Tamri (date-like)." [22] A hundred years ago, a close variety was common in the Jordan valley and around Jerusalem. [23] The bedouin valued the fruit, calling it nabk. It could be dried and kept for winter or made into a paste which was used as bread. [24]

Key Laboratory of Geospace Environment, University of Science and Technology of China, Hefei, China Witch's broom, prevalent in China and Korea, is the main disease affecting jujubes, though plantings in North America currently are not affected by any pests or diseases. [15] In Europe, the last several years have seen some 80%–90% of the jujube crop eaten by insect larvae (see picture), including those of the false codling moth, Thaumatotibia (Cryptophlebia) leucotreta. [16] a b "jujube". Oxford English Dictionary (Onlineed.). Oxford University Press. (Subscription or participating institution membership required.)Figure 5B elucidated the MDA accumulation in jujube during 15-day cold storage. At day 0, the MDA content of jujube in CAP-treated groups was reduced and displayed a time-dependent manner. Then, at day 5, the MDA concentration of jujube in control was not changed, while of that in CAP5 and CAP10 was further decreased, and of that in CAP20 start increasing as compared to day 0. As compared to CAP5 and CAP20, the MDA content of jujube in CAP10 was continually increased but still lower than that of control from days 10 to 15 ( p< 0.05). Discussion Early animal studies have found that jujube extract may interact with some seizure medications, such as carbamazepine, phenytoin, phenobarbitone.

TJ: investigation, methodology, formal analysis, and writing – original draft. CD: methodology and writing – original draft. YX: methodology, validation, and writing – review and editing. YC: data curation, validation, and formal analysis. QX: resources, project administration, and funding acquisition. ZW: conceptualization, resources, writing – review and editing, supervision, and funding acquisition. All authors contribution to the article and approved the submitted version. Funding You should aim for 25 to 35 grams of fiber a day. A diet that’s high in fiber has many benefits, including:Ziziphus jujuba". Germplasm Resources Information Network. Agricultural Research Service, United States Department of Agriculture . Retrieved 11 December 2017. Jujube fruit has been eaten and used in traditional medicine for over 3,000 years. Today, it is popular all over the world. Liddell, Henry George; Scott, Robert. "A Greek-English Lexicon, ζίζυ

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