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The mycological cure rate was higher for K101 versus placebo and a greater proportion of patients treated with K101 reported improvement in their disease. An 8-week open-label multicenter study was conducted to assess whether K101-03, a marketed topical treatment containing propylene glycol, glycerol, urea, and lactic acid, could produce rapid cosmetic improvements in affected nails.
As with K101 [17] , improvements in thickening, discoloration, brittleness and softness were observed at 4 weeks, with discoloration the first physical attribute to show improvement in more than half of participants. Respondents were less likely to engage in sporting or social activities with onychomycosis patients and more likely to feel uncomfortable in their presence [16] . In conclusion, K101-03 was well tolerated and rapidly improved the cosmetic appearance of disease-affected nails, with over three quarters of onychomycosis patients reporting improvements after the first week of treatment.
Onychomycosis, a fungal infection of the toenails and (less frequently) the fingernails, is characterized by discoloration of the nail plate, subungual hyperkeratosis/debris and onycholysis (detachment of all or part of the nail plate from the nail bed). The Effect of K101 Nail Solution on Trichophyton rubrum and Candida albicans growth and ultrastructure. This medication should not be used on a child or teenager who has a fever, especially if the child also has flu symptoms or chicken pox. Kerasal Nail is a clear colorless solution whose ingredients are propylene glycol, urea, lactic acid, disodium EDTA, glycerin, sodium hydroxide and water.
This suggests that formulations containing propylene glycol, urea, and lactic acid are effective, well tolerated, and patient friendly. If the nail bed is damaged it may grow back misshapen but will be a lot easier to manage if thinner. They were also asked whether, compared to baseline, the target nail had become i) less thickened, ii) less discolored, iii) less brittle and iv) softer (Yes/No/Cannot determine).Can I say that people really check for active ingredients in fungal nail solutions and there is non in this. After 4 weeks of treatment, discoloration, thickening, and softness each showed improvements in two thirds of patients; 53. Approximately half of patients showed reduced nail thickening by the end of the second week of treatment.