Liquipak BAC 50 - Benzalkonium Chloride Concentrated 5L

Product Information

It is used as an antimicrobial preservative in numerous medicinal products for nasal route of administration and in many preparations for inhalation use authorised on EU markets. This theory of simultaneous or “cross-selection” suggests that selection of either antiseptic or antibiotic resistance will also select for the other, ultimately resulting in weaker antibacterial therapy and pressure for careful use of both biocides. Benzalkonium chloride is usually non-irritating, and non-sensitizing and is well tolerated in the dilutions normally employed on the skin and mucous membranes. Cleaners for floor and hard surfaces as a disinfectant, such as Lysol and Dettol antibacterial spray and wipes.

Ryall, Julian (2018-07-10). "Japanese nurse investigated over 20 killings at end of shifts to avoid 'nuisance' of telling families of deaths". The Telegraph. ISSN 0307-1235 . Retrieved 2018-08-26. Le chlorure de benzalkonium a aussi une activité spermicide.Solubilité Très soluble dans l'eau, l'alcool, l'acétone ; The first step to the biodegradation of BAC is the fission or splitting of the alkyl chain from the quaternary nitrogen as shown in the diagram. In particular, impermeability by additional or architecturally-complex surface layers in addition to the cellular membrane are commonly exhibited by a variety of microorganisms that render BAC less efficacious.Benzalkonium Chloride | Cosmetics Info". cosmeticsinfo.org. Archived from the original on 2020-11-01 . Retrieved 2021-03-10.

The use concentration of BAC 50 will depend on the particular application and the required degree of antimicrobial activity. Therefore, even at high concentrations, BACs tend to be “non-cidal” and are rather bacteriostatic, mycobacteriostatic, and sporostatic.

Thorup I: Evaluation of health hazards by exposure to Quaternary ammonium compounds, The Institute of Food Safety and Toxicology, Danish Veterinary and Food Administration, [1] In 1947, the first product containing BACs was registered with the Environmental Protection Agency (EPA) in the United States.

Chemical Role(s): surfactant: A substance which lowers the surface tension of the medium in which it is dissolved, and/or the interfacial tension with other phases, and, accordingly, is positively adsorbed at the liquid/vapour and/or at other interfaces.

Although historically benzalkonium chloride has been ubiquitous as a preservative in ophthalmic preparations, its ocular toxicity and irritant properties, in conjunction with consumer demand, have led pharmaceutical companies to increase production of preservative-free preparations, or to replace benzalkonium chloride with preservatives which are less harmful. Its activity depends on the surfactant concentration and also on the bacterial concentration (inoculum) at the moment of the treatment. This substance is identified by SDA Substance Name: C10-C16 alkyl benzyl dimethyl ammonium chloride and SDA Domestic applications include fabric softeners, personal hygiene and cosmetic products, such as shampoos, conditioners, and body lotions, as well as ophthalmic solutions and medications that use the nasal route of delivery.