Thorne Curcumin Phytosome 500 mg (Meriva) - 120 Capsules - 60 Servings

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Liu A, Lou H, Zhao L, Fan P (2006) Validated LC/MS/MS assay for curcumin and tetrahydrocurcumin in rat plasma and application to pharmacokinetic study of phospholipid complex of curcumin. J Pharm Biomed Anal 40(3):720–727. doi: 10.1016/j.jpba.2005.09.032 Fever: A less common side effect that some curcumin users report is an increase in body temperature. If you notice a low-grade fever after supplementing with curcumin, it could be a response to an additive such as bioperine. The side effects of bioperine aren’t well understood, but since it increases curcumin’s bioavailability to a significant extent, it is often included within curcumin supplements. Flatulence: It is considered common to experience flatulence as a side effect from curcumin supplementation. Some estimate that 1 out of 4 users notice an increase in gaseous bloating, accumulation, and/or simply passing gas. In a study among those taking 6 grams of curcumin per day, flatulence was noted as being among the most common side effects. The Allowable Daily Intake (ADI) value of curcumin has been determined by the European Food Safety Authority to be 0-3 mg per kilogram of body weight, or roughly 0-1.4 mg per pound. Curcumin, a hydrophobic polyphenol, is the principal constituent extracted from dried rhizomes of Curcuma longa L. (turmeric). Curcumin is known as a strong anti-oxidant and anti-inflammatory agent that has different pharmacological effects. In addition, several studies have demonstrated that curcumin is safe even at dosages as high as 8g per day; however, instability at physiological pH, low solubility in water and rapid metabolism results in a low oral bioavailability of curcumin. The phytosomal formulation of curcumin (a complex of curcumin with phosphatidylcholine) has been shown to improve curcumin bioavailability. Existence of phospholipids in phytosomes leads to specific physicochemical properties such as amphiphilic nature that allows dispersion in both hydrophilic and lipophilic media. The efficacy and safety of curcumin phytosomes have been shown against several human diseases including cancer, osteoarthritis, diabetic microangiopathy and retinopathy, and inflammatory diseases. This review focuses on the pharmacokinetics as well as pharmacological and clinical effects of phytosomal curcumin.

Frequent bowel movements: Even if you don’t experience diarrhea after taking curcumin, you may notice an increase in your frequency of bowel movements. If prior to supplementing with curcumin you generally experienced a single bowel movement per day, but during supplementation bowel movements increase to 2 or 3 times daily, the curcumin supplement may be the culprit. Perhaps if you experience frequent constipation and/or a suboptimal frequency of bowel movements, this may be a favorable side effect. I was put on a drip and, thankfully, began to recover. Sorry to have rambled, but I feel it is important for people to understand the effects that Curcumin can produce on some of us. I have since read that Curcumin (I think specifically from that grown in India) contains some serious heavy metals which come with their own side effects. In the event that side effects are “mild” and benefits are “moderate” and/or “significant” – continued supplementation may be advantageous. On the other hand, if you’re experiencing a noticeable reduction in inflammation, but also experience severe diarrhea, continued supplementation may not be a practical. No amount of inflammation reduction is worth sacrificing a majority of your day on the toilet. After a lot of tests and treatment, I discovered that I have some inflammation and that taking Aleve once every couple of days helps me tremendously. In addition, I went through an entire month without a migraine. I usually have two hormonal migraines a month. I was so happy and I have been feeling amazing. Then when I was at the chiropractor, she expressed displeasure that I am taking Aleve and told me to take turmeric.Anand P, Kunnumakkara AB, Newman RA, Aggarwal BB (2007) Bioavailability of curcumin: problems and promises. Mol Pharm 4(6):807–818. doi: 10.1021/mp700113r To mitigate potential diarrhea associated with curcumin, be sure to administer it after a large meal and/or consider reducing your dosage. The combination of post-meal ingestion, as well as dosage reduction, may be an effective strategy for preventing curcumin-induced diarrhea. Also keep in mind that sometimes it may take the body a few days to adapt to a newly introduced supplement. https://www.researchgate.net/publication/343430489_Turmeric_Haldi_-_A_strapping_strategy_for_enhancing_the_immune_system_to_reduce_the_effect_of_SARS-CoV-2 Terao K, Nakata D, Fukumi H, Schmid G, Arima H, Hirayama F, Uekama K (2006) Enhancement of oral bioavailability of coenzyme Q10 by complexation with gamma-cyclodextrin in healthy adults. Nutr Res 26:503–508

In the event that you experience a skin rash within 24 and 72 hours after taking and/or using curcumin, it is necessary to consider that you may be allergic. The skin rash may or may not be itchy, but is commonly reddish in color with splotches, patches, and/or spots. These red spots may be noticeable throughout the body and/or concentrated in certain areas. For most users, therapeutic effects of curcumin will trump the side effects. In clinical studies, side effects associated with curcumin supplementation were documented as “mild” and didn’t impair neurological or physical function. If you’d like help determining whether you should continue curcumin supplementation after experiencing unwanted side effects, consult a medical professional. Possible ways to reduce Curcumin side effects Sasaki H, Sunagawa Y, Takahashi K, Imaizumi A, Fukuda H, Hashimoto T, Wada H, Katanasaka Y, Kakeya H, Fujita M, Hasegawa K, Morimoto T (2011) Innovative preparation of curcumin for improved oral bioavailability. Biol Pharm Bull 34(5):660–665

Technologie Phytosome®

However, before you place full blame on the curcumin for your nausea, consider that additives to enhance bioavailability (e.g. bioperine) could also be the culprit. Additionally, consider that taking curcumin with food or after a big meal may decrease likelihood of becoming nauseous from supplementation. Although you may experience nausea from curcumin supplementation, it is likely to be transient and/or negligible as a side effect. Curcumin is the main active ingredient in turmeric. Turmeric is native to Southeast Asia, but is popular all over the world. It is perhaps most popular in India, where it is one of the main spices in curry powders. Its flavor is warm and bitter, and it has a striking yellow color. Zielińska A, et al. (2020). Properties, extraction methods, and delivery systems for curcumin as a natural source of beneficial health effects. Trying to cover his ass. I love doctors of all types. Wish they would really educate themselves on all aspects of supplements. Grrr. Reply