Time 4 GDA Glucose Disposal Agent High Strength Vegan Capsules, 7 Key Ingredients + Berberine Suitable for Men & Women, Support Glucose Metabolism, Weight Management Supplement – 180 Capsules

Product Information

Lan, J., Zhao, Y., Dong, F., Yan, Z., Zheng, W., Fan, J., & Sun, G. (2015). Meta-analysis of the effect and safety of berberine in the treatment of type 2 diabetes mellitus, hyperlipemia and hypertension. Journal of Ethnopharmacology, 161, 69-81 Mounier, R., Lantier, L., Leclerc, J., Sotiropoulos, A., Foretz, M., & Viollet, B. (2011). Antagonistic control of muscle cell size by ampk and mtorc1. Cell Cycle, 10(16), 2640-2646. Thank you for dropping us a line about Time 4 GDA Glucose Disposal Agent. My name is Brian Batcheldor, I consult to Time 4 Nutrition on all matters relating to research and development. In the formulation of a Glucose Disposal Agent formula, there are a few questions we have to ask of ingredients, but there are at least as many hurdles to clear in getting a finished product out there. Of course, number one will always be safety, closely followed by efficacy. Financial viability and sustainability then enter the equation, this is where the wheels start to fall off for Alpha Lipoic Acid. The results of a study by Kumar and colleagues ( 10) also demonstrated Gymnema sylvestre’s ability to enhance glucose uptake and reduce insulin resistance. A clinical trial by Khan et al., ( 22) and colleagues investigated the effects of cinnamon on blood glucose, triglyceride, total cholesterol, HDL cholesterol, and LDL cholesterol levels in people with type 2 diabetes. The results showed that after 40 days, cinnamon reduced the mean fasting serum glucose (18-29%), triglyceride (23-30%), LDL cholesterol (7-27%), and total cholesterol (12-26%) levels; no significant changes were noted in the placebo groups.

It is stated on the couriers delivery note the number of boxes you should receive. If the number of boxes you have received does not match the number stated on the delivery note you must note the number of boxes received on the delivery note by your signature. These products should not be used as a substitute for proper nutrition or exercise. They are intended only to help patients whose weight loss efforts have been unsuccessful using diet and exercise alone manage their weight loss successfully.

Benefits of Glucose Disposal Agents

Chromium is an essential trace mineral that improves insulin sensitivity and enhances protein, carbohydrate, and fat metabolism. Chromium supplementation has been shown to reduce insulin resistance and to help reduce the risk of cardiovascular disease and type 2 diabetes [1]. Berberine The authors conclude that the significant differences and trends for lower muscle hypertrophy and strength gains in the metformin group compared to placebo were likely due to the activation of AMPK, and its inhibition of mTOR. In healthy people: blood glucose levels are tightly regulated by functional pancreatic beta-cells that are able to secrete adequate amounts of insulin when needed. When blood glucose goes up, insulin is secreted and glucose is shuttled to adequate tissues – this process does not need external aid in healthy individuals. In people with diabetes, on the other hand, external aid (drugs, supplements, etc.) are needed to shuttle the blood glucose to tissues since insulin is not being secreted to do its job. Shuttling Glucose Into Muscle Cinnamon extract has been proposed to help with glucose tolerance by AMPK activation, allowing glucose to enter skeletal muscle through GLUT4 transporters (Medagama, 2015). Again, AMPK directly inhibits mTOR, the master regulator of muscle protein synthesis. Keep in mind that we’re talking about cinnamon extract; this is concentrated cinnamon that you would get in pill or concentrated powder form. You probably need a ridiculously high level of regular ground cinnamon bark to actually have measurable effects on muscle. To do this effectively, there are three main ingredients that must be present: alpha lipoic acid, chromium picolinate, and vanadium. The first two ingredients synergize to increase insulin sensitivity by promoting cellular glucose uptake and insulin receptor signaling. Vanadium works independently to increase cellular glucose uptake as well.

Alam et al., ( 4) suggest that the extract of bitter melon showed strong antioxidant and hypoglycaemic activities and has a potential therapeutic benefit in diabetes and obesity related metabolic dysfunction. These beneficial effects are mediated probably by inducing lipid and fat metabolising gene expression and increasing the function of AMPK. For people wanting to lose weight, insulin is often regarded negatively. But for those looking to gain muscle, insulin can be strategically used as an anabolic weapon. In the current study, 109 elderly individuals were split into either a metformin (n=54) or placebo group (n=55). The individuals followed a 14-week progressive resistance training protocol that included chest press, lateral pulldown, bicep curls, tricep extensions, squats, leg press and calf press.

Cinnamon Extract - Cinnamon extract is a favourite GDA ingredient of professional bodybuilders thanks to its ability to reduce blood sugar. Before you go running to the kitchen pantry, though, you should know that we’re talking about cinnamon extract (a highly concentrated form of cinnamon). You’d need a ludicrous amount of regular ground cinnamon to have any significant effect, so don’t bother. Bitter melon is a tropical vine that belongs to the gourd family and is closely related to zucchini, squash, pumpkin, and cucumber. Bitter melon has been shown to improve several markers of long-term blood sugar control, including levels of fructosamine and hemoglobin A1c [4]. Cinnamon Extract A review by Pang et al., ( 18) on the application of berberine (BBR) for treating type 2 diabetes mellitus highlighted the effects of BBR on glucose metabolism. These include improving insulin resistance, promoting insulin secretion, inhibiting gluconeogenesis in liver, stimulating glycolysis in peripheral tissue cells, modulating gut microbiota, reducing intestinal absorption of glucose, and regulating lipids. Several supplements exist on the market that helps control how our bodies react to insulin and these are collectively known as glucose disposal agents (GDA’s). But what are the actual ingredients? Cinnamomum cassia (also known as Chinese cinnamon) is cultivated widely in Southeast asia and has been used for centuries in Traditional Chinese Medicine to treat diabetes, chronic inflammation, and immune deficiency [ 7]. The bark of cinnamon is a rich source of medicinal compounds, notably cinnamaldehyde and eugenol. These antioxidants have ubiquitous actions throughout the body but are especially beneficial for supporting healthy blood glucose levels after consuming a carbohydrate-rich meal [ 8].