The Renal Drug Handbook, 3rd Edition

Product Information

Physical Examination Procedures for Advanced Practitioners and Non-Medical Prescribers - 2nd ed. (2015) The Renal Drug Database is not intended to offer definitive advice or guidance on how drugs should be used in patients with renal impairment, nor is it a comprehensive and complete list of all drugs licensed in the UK. Biologics, Biosimilars and Biobetters: An Introduction for Pharmacists, Physicians and other Health Practitioners(2021) Schrier RW, Gambertoglio JG. Handbook of Drug Therapy in Liver and Kidney Disease. Little, Brown and Co.; 1991. Spironolactone has been found to be carcinogenic in rodents when administered at high doses over a long period of time. Long term use in young patients requires careful consideration.

The Renal Drug Handbook. Fourth Edition (2014) ed. Ashley, C and Dunleavy, A, Radcliffe Publishing Ltd, London. The manufacturers information should always be followed unless a renal specialist advises otherwise. Prescribing or administering a medication outside the manufacturers information may render the medicine being used off-label. Summary of Product Characteristics (SmPC) Short test: 400mg spironolactone is administered daily for four days. If serum potassium increases during administration but drops when discontinued, a presumptive diagnosis of primary hyperaldosteronism should be considered. Hepatotoxicity (including fatalities) has been observed during treatment but the abnormalities have usually been reversible on discontinuation of fluconazole. Patients who develop abnormal liver tests should be monitored for the development of more serious hepatic injury. Discontinue treatment if clinical signs or symptoms consistent with liver disease develop during treatment. Exfoliative cutaneous reactions such as Stevens-Johnson syndrome and toxic epidermal necrolysis have been reported rarely. If a rash develops in a patient treated for a superficial fungal infection which may be attributed to fluconazole, discontinue treatment. If patients with invasive/systemic fungal infections develop rashes, they should be closely monitored and fluconazole discontinued if bullous lesions or erythema multiforme develop.Vaginal candidiasis prophylaxis and treatment (four or more episodes yearly): 150mg every 72 hours for three doses followed by 150mg once weekly maintenance dose for six months.

When transferring from the oral route to the intravenous route or vice versa, there is no need to change the daily dose. Contraindications Patients who tolerate 25mg once daily may have their dose increased to 50mg once daily as clinically indicated. Patients who do not tolerate 25mg once daily may have their dose reduced to 25mg every other day.Children have a higher fluconazole clearance than observed for adults. A dose of 100mg, 200mg and 400mg in adults corresponds to a 3mg/kg, 6mg/kg and 12mg/kg dose in children, respectively. Patients who have previously experienced adverse reactions to quinine including that in tonic water or other beverages should not be prescribed quinine. Pregnancy and Lactation Pregnancy Summary of Product Characteristics: Quinine Sulfate Tablets 200mg. Teva UK Ltd. Revised April 2012.

individual medicine monographs on how to prescribe, prepare and administer the medicine in various types of renal impairment Neonates, infants born prematurely, those with low birth weight, those with an unstable gastrointestinal function or who have serious illnesses may require special consideration. For any infant, if a drug is prescribed to the nursing mother, it should be at the lowest practical dose and for the shortest time. When drug administration is unavoidable and breastfeeding is to continue, minimisation of exposure of the infant to the drug may sometimes be achieved by timing the maternal doses to just after a feeding episode. Infants exposed to drugs via breast milk should be monitored for unusual signs or symptoms. Interactions between the drug received by the infant from the mother's milk and medication prescribed for the infant should also be considered, for example, when the drug given to the infant may prevent metabolism of the drug received via breast milk. Summary of Product Characteristics: Spironolactone Tablets 25mg. Actavis UK Ltd. Revised June 2014. It is strongly recommended that all users read carefully the following information prior to using The Renal Drug Database.There have been a few reported cases of apparently healthy children born after exposure to hydroxycarbamide in-utero. However, the data is too limited to draw conclusions about safety during pregnancy or the long-term growth and development of children exposed in-utero. Children aged 1 month to 18 years: 3mg/kg daily, maximum dose 50mg daily, for two to four weeks (up to a maximum duration of six weeks in tinea pedis). Tinea unguium (onychomycosis): 150mg once weekly. Treatment should be continued until uninfected nail grows. Usually three to six months for fingernails and six to twelve months for toenails. contains pharmacokinetic data to inform how the medicine will be removed, e.g. amount of parent medicine excreted through the kidneys, how any active metabolites are removed, impact of kidney disease on medication half-life